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The science behind a wrinkle-filler: Researchers discover for the first time how product works

By Katie Gazella

University of Michigan Health System

February 19, 2007

University of Michigan study on dermal filler Restylane shows that it causes the skin to create more collagen.

ANN ARBOR, MI – The current battle between the makers of anti-wrinkle products – widely compared with the Coke and Pepsi struggle for superiority – is receiving an injection of scientific understanding with the release of a new study from the University of Michigan Health System.

The study is the first to discover that one of the fillers – known by the brand-name Restylane – works by stretching fibroblasts, the cells in the skin that make collagen, in a way that causes the skin to create new collagen. This new, natural collagen then would contribute to the reduction of the appearance of creases and wrinkles. The study also shows that the product seems to inhibit the breakdown of existing collagen.

"Prior to our research, it has been thought that Restylane's physical volume caused the improvement in the appearance of one's skin," says senior author John J. Voorhees, M.D., the Duncan and Ella Poth Distinguished Professor and chair of the Department of Dermatology at the U-M Medical School.